We want you to be safe and that includes using pest spray's. We also want to make sure you don't end up with a bite from a brown recluse or a spider that might carry MRSA. (trust me that hurts) Researchers at Rutgers University tested 11 different non-synthetic bedbug sprays, and their findings were recently published in the Journal of Economic Entomology. The only one that really killed spiders, etc is EcoRaider . Which is sold at Home Depot.