29/10/2026
Ever notice how a joint can start off bright and uplifting, but by the time you get to the roach, you feel heavy and sedated? That isn’t just in your head—it’s organic chemistry.
In this clip from Episode 172, pharmaceutical scientist Dr. Riley Kirk Riley 🌳💚 breaks down the pyrolysis of cannabis smoke:
1,000°F Combustion: When you light a joint, fragile monoterpenes (the lighter compounds) are volatilized and pulled through on the first few puffs. By the time you’re halfway through, most of those monoterpenes are completely gone or degraded.
The Shift to Sesquiterpenes: What survives the heat and builds up in the remaining flower are heavier sesquiterpenes and cannabinoids. This fundamentally alters the chemical ensemble you inhale toward the end of the session, leading to a much more sedating profile.
“Roaches for Research”: In lab tests analyzing joint roaches, Dr. Kirk’s team found that heavier sesquiterpenes vastly outnumbered monoterpenes, which had almost completely disappeared.
What’s listed on a raw flower COA is only half the story—understanding what survives combustion is the real frontier.
Catch our full conversation on Episode 172 of the Cannabis Cultivation and Science Podcast on YouTube, Spotify, or Apple Podcasts (link in bio)!